Biosensing | Biocatalysis Nanopores are widespread in nature and facilitate the essential transport of water-soluble molecules across bilayers. Replicating this key property with engineered or de-novo pores is scientifically intriguing and additionally leads to powerful biomedical research tools and......

Nucleic Acids Chemistry

Epigenetics | DNA-small molecule interactions Nucleic acids and linker chemistries are important to expand the functional range of DNA strands. For example, fluorophores are chemically attached to facilitate the detection of DNA. The Howorka group has created new nucleotide derivatives which enable the facile.....

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Welcome

Welcome to the Howorka group at University College London. We are excited about membrane nanopores and study, for example, protein pores of pathogenic bacteria to understand their role as gateway for transport across lipid bilayers. In addition, new synthetic pores composed of DNA are engineered to achieve unprecedented molecular control for applications in biosensing, targeted cell killing, and synthetic biology. We also enjoy developing new nucleic acids probes and linker chemistries to enable new discoveries in biological research.